1. Signaling Pathways
  2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. E3 Ligase Ligand-Linker Conjugates Inhibitors

E3 Ligase Ligand-Linker Conjugates Inhibitors

von Hippel-Lindau (VHL)

MDM2

Cereblon

cIAP1

Aryl Hydrocarbon Receptor

TRIM21

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E3 Ligase Ligand-Linker Conjugates
Product Name von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21 Purity
(S,R,S)-AHPC-PEG4-N3
VHL
          99.93%
(S,R,S)-AHPC-PEG5-COOH
VHL
          99.80%
(S,R,S)-AHPC-PEG3-N3
VHL
          99.67%
Thalidomide-NH-CH2-COOH    
Cereblon
      98.17%
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
VHL
          99.01%
Pomalidomide-PEG1-C2-N3    
Cereblon
      99.91%
(S,R,S)-AHPC-PEG1-N3
VHL
          98.18%
Thalidomide-O-PEG4-NHS ester    
Cereblon
     
BODIPY FL thalidomide    
Cereblon
      99.20%
(S,R,S)-AHPC-PEG4-NH2
VHL
          99.51%
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
VHL
          99.77%
(S,R,S)-AHPC-PEG2-N3
VHL
          99.74%
VH032-PEG3-acetylene
VHL
          98.14%
Lenalidomide-C5-NH2 hydrochloride    
Cereblon
      98.44%
Thalidomide-O-amido-PEG4-azide    
Cereblon
      99.19%
Pomalidomide-PEG4-azide    
Cereblon
      99.85%
(S,R,S)-AHPC-amido-C5-acid
VHL
          99.58%
Pomalidomide-PEG4-C-COOH    
Cereblon
      99.10%
Pomalidomide-C2-NH2 hydrochloride    
Cereblon
      99.46%
Thalidomide-O-PEG2-propargyl    
Cereblon
      98.26%
Pomalidomide 4'-PEG5-acid    
Cereblon
     
Pomalidomide 4'-alkylC5-acid    
Cereblon
      98.78%
Thalidomide-4-O-C6-NH2 hydrochloride    
Cereblon
      98.53%
Pomalidomide-PEG3-azide    
Cereblon
      98.88%
Pomalidomide-PEG2-azide    
Cereblon
     
A 410099.1, amine-Boc hydrochloride      
cIAP1
   
Thalidomide-O-C8-COOH    
Cereblon
     
Thalidomide-O-C2-acid    
Cereblon
     
Thalidomide-O-amido-C3-COOH    
Cereblon
      98.43%
Pomalidomide-C7-COOH    
Cereblon
      98.07%
Thalidomide-PEG2-C2-NH2 hydrochloride    
Cereblon
      99.89%
Pomalidomide 4'-PEG3-azide    
Cereblon
     
Nutlin-C1-amido-PEG4-C2-N3  
MDM2
        99.19%
Pomalidomide-PEG4-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-C6-COOH    
Cereblon
      99.67%
Pomalidomide-PEG1-C2-COOH    
Cereblon
      99.76%
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
VHL
          98.06%
Biotin-PEG6-Thalidomide    
Cereblon
      98.51%
Lenalidomide-propargyl-C2-NH2 hydrochloride    
Cereblon
      98.04%
Pomalidomide-PEG3-C2-NH2 TFA    
Cereblon
      99.0%
Pomalidomide-amido-C3-COOH    
Cereblon
      99.51%
(S,R,S)-AHPC-C8-NH2
VHL
         
Thalidomide-NH-PEG3-propionic acid    
Cereblon
      99.72%
(S,R,S)-AHPC-C2-NH2 dihydrochloride
VHL
          98.63%
Thalidomide-O-C5-acid    
Cereblon
     
Pomalidomide-amino-PEG3-NH2 hydrochloride    
Cereblon
      99.52%
Thalidomide-O-amido-C4-N3    
Cereblon
      98.36%
Lenalidomide-acetylene-C5-COOH    
Cereblon
      99.26%
(S,R,S)-AHPC-Me-C5-COOH
VHL
         
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-PEG4-COOH    
Cereblon
      98.55%
Pomalidomide-amido-PEG3-C2-NH2    
Cereblon
      99.55%
Thalidomide-NH-C5-NH2 hydrochloride    
Cereblon
      99.28%
(S,R,S)-AHPC-C3-NH2 hydrochloride
VHL
         
(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
VHL
          99.89%
Pomalidomide-amino-PEG5-NH2 hydrochloride    
Cereblon
      99.58%
Thalidomide-4-O-C5-NH2 hydrochloride    
Cereblon
     
Thalidomide-PEG2-C2-NH2 TFA    
Cereblon
      99.39%
Thalidomide-O-C8-Boc    
Cereblon
     
Thalidomide-O-amido-C4-NH2 hydrochloride    
Cereblon
      98.11%
Thalidomide-Piperazine-PEG1-COOH    
Cereblon
      99.24%
Thalidomide-NH-PEG2-COOH    
Cereblon
      98.65%
(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
VHL
         
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride    
Cereblon
      98.29%
Thalidomide-PEG3-COOH    
Cereblon
      98.05%
(S,R,S)-AHPC-C4-NH2 dihydrochloride
VHL
         
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride    
Cereblon
      98.10%
Thalidomide-Piperazine-PEG3-COOH    
Cereblon
      99.89%
Thalidomide-PEG2-NH2 hydrochloride    
Cereblon
     
Thalidomide-5-PEG4-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-C10-COOH    
Cereblon
     
Thalidomide-C2-amido-C2-COOH    
Cereblon
     
Pomalidomide-C3-NHS ester    
Cereblon
      98.70%
Lenalidomide-C4-NH2 hydrochloride    
Cereblon
      98.85%
Thalidomide-4-O-C2-NH2 hydrochloride    
Cereblon
      99.37%
(S,R,S)-AHPC-C6-NH2
VHL
          98.03%
Thalidomide-O-PEG4-azide    
Cereblon
      98.03%
Thalidomide-propargyl    
Cereblon
      99.97%
Pomalidomide-C12-NH2 hydrochloride    
Cereblon
     
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH    
Cereblon
     
Thalidomide-O-amido-C3-NH2 TFA    
Cereblon
      99.58%
Thalidomide-NH-C6-NH-Boc    
Cereblon
     
Thalidomide-NH-C6-NH2 TFA    
Cereblon
      99.82%
Thalidomide-NH-PEG2-C2-NH-Boc    
Cereblon
      98.37%
Thalidomide-O-amido-C6-NH2 TFA    
Cereblon
      99.82%
Thalidomide-PEG4-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-amido-PEG3-C2-NH2    
Cereblon
     
Thalidomide-Piperazine-PEG1-NH2    
Cereblon
     
(S,R,S)-AHPC-PEG5-Boc
VHL
         
Thalidomide-O-amido-C3-PEG3-C1-NH2    
Cereblon
      99.08%
Pomalidomide-PEG6-NH2 hydrochloride    
Cereblon
      98.01%
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA    
Cereblon
      99.28%
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride    
Cereblon
     
Thalidomide-4-O-C4-NH2 hydrochloride    
Cereblon
      99.35%
Thalidomide-O-amido-C4-NH2    
Cereblon
     
Thalidomide-Piperazine-PEG2-NH2    
Cereblon
     
Thalidomide-O-amido-PEG2-C2-NH2 TFA    
Cereblon
      99.72%
Thalidomide-Piperazine-PEG2-COOH    
Cereblon
      99.79%
Thalidomide-piperazine-Boc    
Cereblon
      98.82%
Pomalidomide-PEG4-C2-NH2    
Cereblon
     
Thalidomide-NH-PEG3-COOH    
Cereblon
      98.90%
(S,R,S)-AHPC-C8-NH2 hydrochloride
VHL
         
(S,R,S)-AHPC-Me-C10-Br
VHL
         
(S,R,S)-AHPC-PEG3-NH2
VHL
          99.26%
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
VHL
         
Thalidomide-PEG5-COOH    
Cereblon
      98.09%
(S,R,S)-AHPC-C6-NH2 hydrochloride
VHL
         
(S,R,S)-AHPC-O-Ph-PEG1-NH2
VHL
         
(S,R,S)-AHPC-PEG2-NH2
VHL
         
Thalidomide-PEG4-COOH    
Cereblon
     
Pomalidomide-PEG6-butyl iodide    
Cereblon
      98.35%
Thalidomide-Propargyne-PEG1-COOH    
Cereblon
      99.62%
Thalidomide-Propargyne-PEG3-COOH    
Cereblon
      98.01%
Pomalidomide-amido-C1-Br    
Cereblon
     
Thalidomide-Propargyne-PEG2-COOH    
Cereblon
      99.07%
(S,R,S)-AHPC-PEG3-propionic acid
VHL
         
Pomalidomide-C3-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-amido-C8-NH2 TFA    
Cereblon
      99.43%
Thalidomide-Piperazine 5-fluoride    
Cereblon
     
Thalidomide-Piperazine-Piperidine hydrochloride    
Cereblon
      98.73%
Pomalidomide-PEG3-C2-NH2    
Cereblon
     
(S,R,S)-AHPC-C4-NH2 hydrochloride
VHL
         
Thalidomide-4-O-C10-COOH    
Cereblon
      99.14%
Thalidomide-O-PEG4-amine    
Cereblon
     
Thalidomide-NH-PEG3-NH-Boc    
Cereblon
     
Thalidomide-PEG4-Propargyl    
Cereblon
     
Lenalidomide-C5-amido-Boc    
Cereblon
     
Thalidomide-O-C6-azide    
Cereblon
      99.71%
Thalidomide-NH-C8-NH2 hydrochloride    
Cereblon
     
Pomalidomide-PEG3-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-PEG5-NH2 hydrochloride    
Cereblon
     
Glutarimide-Isoindolinone-NH-PEG3-COOH    
Cereblon
      99.12%
Pomalidomide-PEG4-Ph-NH2    
Cereblon
      ≥98.0%
Thalidomide-5-CH2-NH2 hydrochloride    
Cereblon
      98.55%
Thalidomide-NH-PEG1-NH2 hydrochloride    
Cereblon
      99.59%
Thalidomide-O-amido-PEG3-C2-NH2 TFA    
Cereblon
      99.55%
Thalidomide-NH-C6-NH2 hydrochloride    
Cereblon
      99.62%
Thalidomide-4-O-C3-NH2 hydrochloride    
Cereblon
     
Thalidomide-5-PEG3-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-PEG4-amine hydrochloride    
Cereblon
     
Thalidomide-O-amido-C4-NH2 TFA    
Cereblon
      99.92%
Pomalidomide-amino-PEG4-NH2    
Cereblon
     
Thalidomide-4-O-C8-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-C6-NHBoc    
Cereblon
     
Glutarimide-Isoindolinone-NH-PEG4-COOH    
Cereblon
      99.52%
Glutarimide-Isoindolinone-NH-PEG2-COOH    
Cereblon
      98.51%
(S,R,S)-AHPC-C1-Br
VHL
          ≥98.0%
Pomalidomide-amino-PEG4-NH2 hydrochloride    
Cereblon
      99.27%
Thalidomide-Piperazine-PEG2-NH2 diTFA    
Cereblon
      99.73%
Thalidomide-Piperazine-PEG1-NH2 diTFA    
Cereblon
      99.43%
Pomalidomide-C4-NH2 hydrochloride    
Cereblon
      99.24%
cIAP1 Ligand-Linker Conjugates 1      
cIAP1
   
Thalidomide-O-C3-acid    
Cereblon
     
Thalidomide-O-amido-C6-NH2    
Cereblon
     
Thalidomide-4-O-C10-NH2    
Cereblon
     
Thalidomide-4-O-C6-NH2    
Cereblon
     
(S,R,S)-AHPC-C3-NH2 TFA
VHL
         
Thalidomide-O-amide-C5-NH2    
Cereblon
     
Thalidomide-PEG5-NH2    
Cereblon
     
Thalidomide-O-amido-C3-NH2    
Cereblon
     
Thalidomide-O-amido-C8-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-amido-PEG-C2-NH2    
Cereblon
     
Thalidomide-5-PEG4-NH2    
Cereblon
     
Thalidomide-5-PEG3-NH2    
Cereblon
     
Thalidomide-PEG2-NH2    
Cereblon
     
Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride    
Cereblon
     
Thalidomide-O-amido-PEG2-C2-NH2    
Cereblon
     
Thalidomide-4-O-C7-NH2    
Cereblon
     
Thalidomide-O-amide-C5-NH2 TFA    
Cereblon
     
Lenalidomide-PEG3-iodine    
Cereblon
     
Thalidomide-Piperazine-PEG3-NH2    
Cereblon
     
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2    
Cereblon
     
Thalidomide-NH-PEG7    
Cereblon
     
Thalidomide-NH-C2-PEG3-OH    
Cereblon
     
Lenalidomide-C5-NH2 TFA    
Cereblon
      98.94%
Thalidomide-PEG3-NH2    
Cereblon
     
Thalidomide-Piperazine-Piperidine    
Cereblon
     
(S,R,S)-AHPC-C10-NH2
VHL
         
Thalidomide-PEG2-C2-NH2    
Cereblon
     
Thalidomide-4-O-C8-NH2    
Cereblon
     
Thalidomide-4-O-C6-NH2 TFA    
Cereblon
     
Thalidomide-NH-PEG4-MS    
Cereblon
     
Thalidomide-NH-C4-NH2 TFA    
Cereblon
     
Thalidomide-NH-C6-NH2    
Cereblon
     
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride    
Cereblon
     
(S,R,S)-AHPC-C8-NH2 dihydrochloride
VHL
         
Pomalidomide-PEG2-Tos    
Cereblon
     
(S,R,S)-AHPC-C6-NH2 dihydrochloride
VHL
         
Thalidomide-NH-C4-NH-Boc    
Cereblon
      99.64%
(S,R,S)-AHPC-PEG1-OTs
VHL
         
(S,R,S)-AHPC-C3-NH2
VHL
         
VHL Ligand-Linker Conjugates 15
VHL
         
(S,R,S)-AHPC-C5-COOH
VHL
          98.81%
(S,R,S)-AHPC-C10-NH2 dihydrochloride
VHL
         
(S,R,S)-AHPC-PEG1-NH2 dihydrochloride
VHL
         
(S,R,S)-AHPC-Me-C10-NH2
VHL
         
Pomalidomide-amido-C3-piperazine-N-Boc    
Cereblon
     
Thalidomide-O-amido-PEG4-C2-NH2    
Cereblon
     
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc    
Cereblon
     
Pomalidomide-amido-C4-amido-C6-NH-Boc    
Cereblon
     
(S,R,S)-AHPC-C4-NH2
VHL
         
Pom-8PEG    
Cereblon
     
Thalidomide-O-C11-acid    
Cereblon
     
Thalidomide-O-C4-NH2    
Cereblon
     
Thalidomide-4-O-C5-NH2    
Cereblon
     
Thalidomide-NH-amido-PEG2-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-amido-PEG1-C2-NH2    
Cereblon
     
Thalidomide-5-NH-PEG2-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-amido-PEG1-C2-NH2 hydrochloride    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 2      
cIAP1
   
(S,R,S)-AHPC-C2-NH2
VHL
         
Thalidomide-NH-amido-PEG3-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-amido-C4-NH2 hydrochloride    
Cereblon
     
(S,R,S)-AHPC-C7-amine
VHL
         
Thalidomide-O-PEG4-Boc    
Cereblon
     
Thalidomide-4-C3-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc    
Cereblon
     
Thalidomide-NH-CH2-COO(t-Bu)    
Cereblon
     
Thalidomide-NH-amido-C8-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-amido-PEG4-C2-NH2    
Cereblon
     
Thalidomide-NH-amido-C6-NH2    
Cereblon
     
Thalidomide-O-amido-C6-NH2 hydrochloride    
Cereblon
      99.32%
Thalidomide-NH-amido-C3-NH2    
Cereblon
     
Pomalidomide-C4-NH2    
Cereblon
     
Thalidomide-N-C3-O-C4-O-C3-OH    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 3      
cIAP1
   
Thalidomide-NH-amido-C3-NH2 hydrochloride    
Cereblon
     
VHL Ligand-Linker Conjugates 17
VHL
         
cIAP1 Ligand-Linker Conjugates 4      
cIAP1
   
Boc-A 410099.1 amide-alkylC4-amine      
cIAP1
   
(S,R,S)-AHPC-PEG1-NH2
VHL
         
Pomalidomide-amino-PEG3-NH2    
Cereblon
     
(S,R,S)-AHPC-C1-NH2
VHL
         
Thalidomide-NH-C5-NH2    
Cereblon
     
Thalidomide-NH-PEG8-Ts    
Cereblon
     
Thalidomide-Piperazine 5-fluoride hydrochloride    
Cereblon
     
Thalidomide-NH-C8-NH2    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 5      
cIAP1
   
AhR Ligand-Linker Conjugates 1        
Aryl Hydrocarbon Receptor
 
Amino-PEG6-Thalidomide    
Cereblon
     
A 410099.1, amine-Boc      
cIAP1
   
Thalidomide-4-O-CH2-COO(t-Bu)    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 6 hydrochloride      
cIAP1
   
Pomalidomide-C6-NHS ester    
Cereblon
     
Acepromazine-1-Piperazinepropanamine          
TRIM21
Pomalidomide-cyclopentane-amide-Alkyne    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 15 hydrochloride      
cIAP1
   
(S,R,S)-AHPC-C1-NH2 hydrochloride
VHL
          98.08%
Pomalidomide-C3-NH2    
Cereblon
     
Thalidomide-amido-PEG2-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-amido-C5-NH2    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 7      
cIAP1
   
Thalidomide-4-O-C2-NH2    
Cereblon
     
(S,R,S)-AHPC-C5-NH2
VHL
         
Thalidomide-NH-amido-PEG4-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-C3-NH2    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 8      
cIAP1
   
cIAP1 Ligand-Linker Conjugates 9      
cIAP1
   
cIAP1 Ligand-Linker Conjugates 10      
cIAP1
   
Thalidomide-NH-PEG1-NH2    
Cereblon
     
Thalidomide-O-PEG4-amine TFA    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 11      
cIAP1
   
cIAP1 Ligand-Linker Conjugates 12      
cIAP1
   
Lenalidomide-C5-acid    
Cereblon
     
A 410099.1 amide-PEG3-amine-Boc      
cIAP1
   
Thalidomide-NH-amido-PEG2-C2-NH2    
Cereblon
     
Thalidomide-NH-amido-C5-NH2 hydrochloride    
Cereblon
     
Thalidomide-O-C7-acid    
Cereblon
      98.55%
(S,R,S)-AHPC-C2-PEG4-N3
VHL
         
Thalidomide-NH-amido-C4-NH2    
Cereblon
     
Thalidomide-PEG3-NH2 hydrochloride    
Cereblon
      98.02%
cIAP1 Ligand-Linker Conjugates 13      
cIAP1
   
A 410099.1 amide-PEG2-amine-Boc      
cIAP1
   
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
VHL
          99.31%
cIAP1 Ligand-Linker Conjugates 14      
cIAP1
   
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride      
cIAP1
   
Thalidomide-4-NH-PEG1-NH2 TFA    
Cereblon
     
Thalidomide-O-C4-COOH    
Cereblon
     
Thalidomide-5-PEG2-Cl    
Cereblon
     
cIAP1 Ligand-Linker Conjugates 15      
cIAP1
   
Thalidomide-NH-amido-C2-NH2    
Cereblon
     
Thalidomide-NH-PEG1-NH2 diTFA    
Cereblon
     
Thalidomide-NH-amido-C2-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-(CH2)2-NH2 TFA    
Cereblon
     
N-Boc-SBP-0636457-O-C3-COOH      
cIAP1
   
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride      
cIAP1
   
Thalidomide-O-amido-PEG4-propargyl    
Cereblon
     
Thalidomide-5-propargyne-NH2 hydrochloride    
Cereblon
     
Thalidomide-NH-amido-PEG3-C2-NH2    
Cereblon
     
Thalidomide-NH-amido-C8-NH2    
Cereblon
     
Thalidomide-amido-PEG2-NH2    
Cereblon
     
Thalidomide-5-propoxyethanamine    
Cereblon
     
Thalidomide-NH-amido-C6-NH2 hydrochloride    
Cereblon
     
Pomalidomide-amino-PEG5-NH2    
Cereblon
     
Pomalidomide 4'-PEG6-azide    
Cereblon
     
Thalidomide-piperazine-piperidine-2-F-Ph-CHO    
Cereblon
     
Pomalidomide-PEG3-OH    
Cereblon
     
Pomalidomide-PEG2-OH    
Cereblon
     
Pomalidomide-C2-acid    
Cereblon
     
Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride    
Cereblon
     
Thalidomide-O-amido-C8-NH2    
Cereblon
     
VH032-thiol-C6-NH2
VHL